6FH5

PI3Kg IN COMPLEX WITH Compound 7

Summary for 6FH5

• Entry DOI: 10.2210/pdb6fh5/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one (3 entities in total)
• Functional Keywords: kinase, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 111087.51

Authors

Petersen, J.,Barlaam, B. (deposition date: 2018-01-12, release date: 2019-01-30, Last modification date: 2024-05-01)

• Primary citation: Barlaam, B.,Cadogan, E.,Cambell, A.,Colclough, N.,Dishington, A.,Durant, S.,Goldberg, K.,Hassall, L.A.,Hughes, G.D.,MacFaul, P.A.,McGuire, T.M.,Pass, M.,Patel, A.,Pearson, S.,Petersen, J.,Pike, K.G.,Robb, G.,Stratton, N.,Xin, N.,Zhai, B.; Discovery and Optimisation of a Novel Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent and Selective Ataxia Telangiectasia Mutated (ATM) inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.84 Å)