6FFB

17beta-hydroxysteroid dehydrogenase 14 variant S205 - mutant Q148A - in complex with a nonsteroidal inhibitor

Summary for 6FFB

Entry DOI	10.2210/pdb6ffb/pdb
Descriptor	17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
Functional Keywords	17b-hsd14, mutation, inhibition, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29803.53
Authors	Bertoletti, N.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. (deposition date: 2018-01-05, release date: 2019-01-30, Last modification date: 2024-01-17)
Primary citation	Badran, M.J.,Bertoletti, N.,Keils, A.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. Mutational and structural studies uncover crucial amino acids determining activity and stability of 17 beta-HSD14. J.Steroid Biochem.Mol.Biol., 189:135-144, 2019 Cited by PubMed: 30836176 DOI: 10.1016/j.jsbmb.2019.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation