6FFA
FMDV Leader protease bound to substrate ISG15
Summary for 6FFA
Entry DOI | 10.2210/pdb6ffa/pdb |
Descriptor | Lbpro, Ubiquitin-like protein ISG15, GLYCEROL, ... (5 entities in total) |
Functional Keywords | leader protease, deisgylase, deubiquitinase, hydrolase |
Biological source | Foot-and-mouth disease virus More |
Cellular location | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03305 Cytoplasm : P05161 |
Total number of polymer chains | 2 |
Total formula weight | 28614.07 |
Authors | Swatek, K.N.,Pruneda, J.N.,Komander, D. (deposition date: 2018-01-05, release date: 2018-02-21, Last modification date: 2024-01-17) |
Primary citation | Swatek, K.N.,Aumayr, M.,Pruneda, J.N.,Visser, L.J.,Berryman, S.,Kueck, A.F.,Geurink, P.P.,Ovaa, H.,van Kuppeveld, F.J.M.,Tuthill, T.J.,Skern, T.,Komander, D. Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115:2371-2376, 2018 Cited by PubMed: 29463763DOI: 10.1073/pnas.1710617115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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