6F6Z

Mouse Thymidylate Synthase Cocrystallized with N(4)OHdCMP and Soaked in Methylenetetrahydrofolate

Summary for 6F6Z

• Entry DOI: 10.2210/pdb6f6z/pdb
• Descriptor: Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), (2~{S})-2-[[4-[[(6~{R})-2-azanyl-4-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, ... (4 entities in total)
• Functional Keywords: enzyme, inhibitor, cofactor, transferase
• Biological source: Mus musculus (House Mouse)
• Total number of polymer chains: 2
• Total formula weight: 71567.34

Authors

Wilk, P.,Jarmula, A.,Maj, P.,Rode, W. (deposition date: 2017-12-06, release date: 2019-01-30, Last modification date: 2024-01-17)

• Primary citation: Maj, P.,Jarmula, A.,Wilk, P.,Prokopowicz, M.,Rypniewski, W.,Zielinski, Z.,Dowiercial, A.,Bzowska, A.,Rode, W.; Molecular Mechanism of Thymidylate Synthase Inhibition by N4-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies; Int J Mol Sci, 22:-, 2021; PubMed: 33946210; DOI: 10.3390/ijms22094758

Experimental method

X-RAY DIFFRACTION (2.127 Å)