6F28

Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2'-Amino-2'-carboxyethyl]-6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.4A

Summary for 6F28

• Entry DOI: 10.2210/pdb6f28/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 3,Glutamate receptor ionotropic, kainate 3, ZINC ION, (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, ... (6 entities in total)
• Functional Keywords: ionotropic glutamate receptor, gluk3, ligand binding domain, membrane protein., membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P42264
• Total number of polymer chains: 2
• Total formula weight: 59222.86

Authors

Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2017-11-23, release date: 2018-02-28, Last modification date: 2024-01-17)

• Primary citation: Brogi, S.,Brindisi, M.,Butini, S.,Kshirsagar, G.U.,Maramai, S.,Chemi, G.,Gemma, S.,Campiani, G.,Novellino, E.,Fiorenzani, P.,Pinassi, J.,Aloisi, A.M.,Gynther, M.,Venskutonyte, R.,Han, L.,Frydenvang, K.,Kastrup, J.S.,Pickering, D.S.; ( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.; J. Med. Chem., 61:2124-2130, 2018; PubMed: 29451794; DOI: 10.1021/acs.jmedchem.8b00099

Experimental method

X-RAY DIFFRACTION (2.4 Å)