6EOR

DPP9 - 1G244

Summary for 6EOR

• Entry DOI: 10.2210/pdb6eor/pdb
• Descriptor: Dipeptidyl peptidase 9, (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione (3 entities in total)
• Functional Keywords: dpp9, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Cytoplasm, cytosol . Isoform 2: Nucleus : Q86TI2
• Total number of polymer chains: 4
• Total formula weight: 398871.13

Authors

Ross, B.R.,Huber, R. (deposition date: 2017-10-10, release date: 2018-02-07, Last modification date: 2024-01-17)

• Primary citation: Ross, B.,Krapp, S.,Augustin, M.,Kierfersauer, R.,Arciniega, M.,Geiss-Friedlander, R.,Huber, R.; Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.; Proc. Natl. Acad. Sci. U.S.A., 115:E1437-E1445, 2018; PubMed: 29382749; DOI: 10.1073/pnas.1717565115

Experimental method

X-RAY DIFFRACTION (2.9 Å)