6EIE
Ras guanine nucleotide exchange factor SOS2 (Rem-cdc25), with surface mutations
Summary for 6EIE
Entry DOI | 10.2210/pdb6eie/pdb |
Descriptor | Son of sevenless homolog 2 (2 entities in total) |
Functional Keywords | guanine exchange factor, gef, sos2, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57370.68 |
Authors | Hillig, R.C.,Moosmayer, D.,Mastouri, J. (deposition date: 2017-09-19, release date: 2019-02-06, Last modification date: 2024-01-17) |
Primary citation | Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Werbeck, N.D.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Mastouri, J.,Petersen, K.,Siemeister, G.,Kahmann, J.D.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116:2551-2560, 2019 Cited by PubMed: 30683722DOI: 10.1073/pnas.1812963116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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