6E8Q

S. CEREVISIAE CYP51 COMPLEXED WITH Posaconazole

Summary for 6E8Q

• Entry DOI: 10.2210/pdb6e8q/pdb
• Related: 5UL0
• Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (6 entities in total)
• Functional Keywords: posaconazole, cyp51, sterol biosynthesis, oxidoreductase
• Biological source: Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 63951.37

Authors

Tyndall, J.D.,Keniya, M.V.,Sabherwal, M.,Monk, B.C. (deposition date: 2018-07-30, release date: 2018-09-05, Last modification date: 2023-10-11)

• Primary citation: Monk, B.C.,Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Graham, D.O.,Hassan, H.F.,Chen, D.,Tyndall, J.D.A.; Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.; Antimicrob. Agents Chemother., 63:-, 2019; PubMed: 30397057; DOI: 10.1128/AAC.02114-18

Experimental method

X-RAY DIFFRACTION (2.2 Å)