6E37

O-GlcNAc Transferase in complex with covalent inhibitor

Summary for 6E37

• Entry DOI: 10.2210/pdb6e37/pdb
• Descriptor: O-GlcNAc transferase subunit p110, TYR-PRO-GLY-GLY-SER-THR-PRO-VAL-SER-SER-ALA-ASN, (2S,3R,4R,5S,6R)-3-[(2E)-but-2-enoylamino]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), ... (4 entities in total)
• Functional Keywords: o-glcnac transferase, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 83022.53

Authors

Li, H.,Jiang, J. (deposition date: 2018-07-13, release date: 2019-11-06, Last modification date: 2020-01-01)

• Primary citation: Worth, M.,Hu, C.W.,Li, H.,Fan, D.,Estevez, A.,Zhu, D.,Wang, A.,Jiang, J.; Targeted covalent inhibition of O-GlcNAc transferase in cells.; Chem.Commun.(Camb.), 55:13291-13294, 2019; PubMed: 31626249; DOI: 10.1039/c9cc04560k

Experimental method

X-RAY DIFFRACTION (2.531 Å)