6DCF
Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A
Summary for 6DCF
Entry DOI | 10.2210/pdb6dcf/pdb |
Descriptor | RNA polymerase-binding protein RbpA, SULFATE ION, ZINC ION, ... (15 entities in total) |
Functional Keywords | inhibitor, complex, rna polymerase, transcription-dna-antibiotic complex, transcription/dna/antibiotic |
Biological source | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) More |
Total number of polymer chains | 9 |
Total formula weight | 447307.40 |
Authors | Lilic, M.,Darst, S.A.,Campbell, E.A. (deposition date: 2018-05-06, release date: 2018-09-05, Last modification date: 2023-10-11) |
Primary citation | Peek, J.,Lilic, M.,Montiel, D.,Milshteyn, A.,Woodworth, I.,Biggins, J.B.,Ternei, M.A.,Calle, P.Y.,Danziger, M.,Warrier, T.,Saito, K.,Braffman, N.,Fay, A.,Glickman, M.S.,Darst, S.A.,Campbell, E.A.,Brady, S.F. Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9:4147-4147, 2018 Cited by PubMed: 30297823DOI: 10.1038/s41467-018-06587-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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