6D2U
Solution structure of a ultra-high affinity macrocycle bound to HIV-1 TAR RNA
Summary for 6D2U
Entry DOI | 10.2210/pdb6d2u/pdb |
NMR Information | BMRB: 30452 |
Descriptor | DAB-VAL-ARG-THR-ARG-LYS-GLY-ARG-ARG-ILE-NOR-ILE-DPR-PRO, RNA (29-MER) (2 entities in total) |
Functional Keywords | macrocycle inhibitor, complex, hiv-1 tar, tat, p-tefb, rna, peptide-rna complex, peptide/rna |
Biological source | synthetic construct More |
Total number of polymer chains | 2 |
Total formula weight | 11004.64 |
Authors | Shortridge, M.D.,Varani, G. (deposition date: 2018-04-13, release date: 2018-12-12, Last modification date: 2023-11-15) |
Primary citation | Shortridge, M.D.,Wille, P.T.,Jones, A.N.,Davidson, A.,Bogdanovic, J.,Arts, E.,Karn, J.,Robinson, J.A.,Varani, G. An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb. Nucleic Acids Res., 47:1523-1531, 2019 Cited by PubMed: 30481318DOI: 10.1093/nar/gky1197 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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