6CZ5

Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C

Summary for 6CZ5

Entry DOI	10.2210/pdb6cz5/pdb
Descriptor	ATP-dependent RNA helicase DDX3X, 5'-O-[(R)-hydroxy(propanoylamino)phosphoryl]adenosine (2 entities in total)
Functional Keywords	inhibitor, dead-box protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	54512.55
Authors	Barkovich, K.J.,Moore, M.K.,Hu, Q.,Shokat, K.M. (deposition date: 2018-04-08, release date: 2018-08-08, Last modification date: 2023-10-04)
Primary citation	Barkovich, K.J.,Moore, M.K.,Hu, Q.,Shokat, K.M. Chemical genetic inhibition of DEAD-box proteins using covalent complementarity. Nucleic Acids Res., 46:8689-8699, 2018 Cited by PubMed: 30102385 DOI: 10.1093/nar/gky706 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation