6CRG

Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099

Summary for 6CRG

Entry DOI	10.2210/pdb6crg/pdb
Related	6CRF
Descriptor	Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, SULFATE ION, ... (5 entities in total)
Functional Keywords	shp2, ptpn11, protein tyrosine phosphatase, e76k, gain of function mutant, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, phosphatase, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	122175.27
Authors	Stams, T.,Fodor, M. (deposition date: 2018-03-17, release date: 2018-11-07, Last modification date: 2023-10-04)
Primary citation	LaRochelle, J.R.,Fodor, M.,Vemulapalli, V.,Mohseni, M.,Wang, P.,Stams, T.,LaMarche, M.J.,Chopra, R.,Acker, M.G.,Blacklow, S.C. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9:4508-4508, 2018 Cited by PubMed: 30375388 DOI: 10.1038/s41467-018-06823-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation