6CQ0

TBK1 in Complex with Dimethyl Amino Analog of Amlexanox

Summary for 6CQ0

Entry DOI	10.2210/pdb6cq0/pdb
Descriptor	Serine/threonine-protein kinase TBK1, 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid (2 entities in total)
Functional Keywords	tbk1, kinase, amlexanox, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	76367.28
Authors	Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2018-03-14, release date: 2018-12-05, Last modification date: 2023-10-04)
Primary citation	Beyett, T.S.,Gan, X.,Reilly, S.M.,Gomez, A.V.,Chang, L.,Tesmer, J.J.G.,Saltiel, A.R.,Showalter, H.D. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26:5443-5461, 2018 Cited by PubMed: 30270002 DOI: 10.1016/j.bmc.2018.09.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.19 Å)

Structure validation