6CE2

Crystal structure of Myotoxin I (MjTX-I) from Bothrops moojeni complexed to inhibitor suramin

Summary for 6CE2

• Entry DOI: 10.2210/pdb6ce2/pdb
• Related: 3T0R
• Descriptor: Basic phospholipase A2 homolog 1, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, ... (4 entities in total)
• Functional Keywords: myotoxin i, mjtx-i, pla2-like, suramin, toxin
• Biological source: Bothrops moojeni (Lance-headed viper)
• Total number of polymer chains: 2
• Total formula weight: 29588.44

Authors

Salvador, G.H.M.,Fontes, M.R.M. (deposition date: 2018-02-10, release date: 2018-07-25, Last modification date: 2023-10-04)

• Primary citation: Salvador, G.H.M.,Dreyer, T.R.,Gomes, A.A.S.,Cavalcante, W.L.G.,Dos Santos, J.I.,Gandin, C.A.,de Oliveira Neto, M.,Gallacci, M.,Fontes, M.R.M.; Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism.; Sci Rep, 8:10317-10317, 2018; PubMed: 29985425; DOI: 10.1038/s41598-018-28584-7

Experimental method

X-RAY DIFFRACTION (2.15 Å)