6C9A

Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state

Summary for 6C9A

• Entry DOI: 10.2210/pdb6c9a/pdb
• Related: 6C96
• EMDB information: 7434 7435
• Descriptor: Two pore calcium channel protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, ... (4 entities in total)
• Functional Keywords: ion channel, membrane protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 193613.87

Authors

She, J.,Guo, J.,Chen, Q.,Bai, X.,Jiang, Y. (deposition date: 2018-01-25, release date: 2018-04-04, Last modification date: 2020-07-29)

• Primary citation: She, J.,Guo, J.,Chen, Q.,Zeng, W.,Jiang, Y.,Bai, X.C.; Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.; Nature, 556:130-134, 2018; PubMed: 29562233; DOI: 10.1038/nature26139

Experimental method

ELECTRON MICROSCOPY (3.2 Å)