6C0M

The synthesis, biological evaluation and structural insights of unsaturated 3-N-substituted sialic acids as probes of human parainfluenza virus-3 haemagglutinin-neuraminidase

Summary for 6C0M

• Entry DOI: 10.2210/pdb6c0m/pdb
• Descriptor: Hemagglutinin-neuraminidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: hemagglutinin-neuraminidase, inhibitor, sialic acid, human parainfluenza virus type 3, sialidase, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human respirovirus 3
• Total number of polymer chains: 2
• Total formula weight: 99974.84

Authors

Dirr, L.,Ve, T.,von Itzstein, M. (deposition date: 2018-01-01, release date: 2018-06-27, Last modification date: 2023-10-04)

• Primary citation: Pascolutti, M.,Dirr, L.,Guillon, P.,Van Den Bergh, A.,Ve, T.,Thomson, R.J.,von Itzstein, M.; Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes.; ACS Chem. Biol., 13:1544-1550, 2018; PubMed: 29693380; DOI: 10.1021/acschembio.8b00150

Experimental method

X-RAY DIFFRACTION (1.83 Å)