6BYF

Crystal structure of the core catalytic domain of PP-IP phosphatase SIW14 from S. cerevisiae in complex with citrate

Summary for 6BYF

Entry DOI	10.2210/pdb6byf/pdb
Descriptor	Tyrosine-protein phosphatase SIW14, CITRIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	protein tyrosine phosphatase, phosphatase, inositol, inositol polyphosphate, inositol pyrophosphate, substrate specificity, transferase
Biological source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Cellular location	Cytoplasm : P53965
Total number of polymer chains	9
Total formula weight	181406.55
Authors	Wang, H.,Shears, S.B. (deposition date: 2017-12-20, release date: 2018-03-21, Last modification date: 2022-03-16)
Primary citation	Wang, H.,Gu, C.,Rolfes, R.J.,Jessen, H.J.,Shears, S.B. Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. J. Biol. Chem., 293:6905-6914, 2018 Cited by PubMed: 29540476 DOI: 10.1074/jbc.RA117.001670 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation