6BRD

Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD

Replaces:  5VQC

Summary for 6BRD

• Entry DOI: 10.2210/pdb6brd/pdb
• Related: 5VQB
• Descriptor: Rifampin monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, RIFAMPICIN, ... (6 entities in total)
• Functional Keywords: rifampin, rifamycin, antibiotic resistance, monooxygenase, oxidoreductase, fad, flavin adenine dinucleotide, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious disease
• Biological source: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
• Total number of polymer chains: 3
• Total formula weight: 162615.23

Authors

Cox, G.,Kelso, J.,Stogios, P.J.,Savchenko, A.,Anderson, W.F.,Wright, G.D.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-11-30, release date: 2017-12-13, Last modification date: 2023-10-04)

• Primary citation: Koteva, K.,Cox, G.,Kelso, J.K.,Surette, M.D.,Zubyk, H.L.,Ejim, L.,Stogios, P.,Savchenko, A.,Sorensen, D.,Wright, G.D.; Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.; Cell Chem Biol, 25:403-412.e5, 2018; PubMed: 29398560; DOI: 10.1016/j.chembiol.2018.01.009

Experimental method

X-RAY DIFFRACTION (3.32 Å)