6BQ8

Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP

Summary for 6BQ8

• Entry DOI: 10.2210/pdb6bq8/pdb
• Descriptor: cGMP-dependent protein kinase 2, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... (5 entities in total)
• Functional Keywords: protein kinase g, regulatory domain, neutron crystallography, activator, hydrogen bonding, protonation state, signaling protein, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 18087.98

Authors

Kim, C.,Kovalevsky, A.,Gerlits, O. (deposition date: 2017-11-27, release date: 2018-03-21, Last modification date: 2024-04-03)

• Primary citation: Gerlits, O.,Campbell, J.C.,Blakeley, M.P.,Kim, C.,Kovalevsky, A.; Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.; Biochemistry, 57:1833-1837, 2018; PubMed: 29517905; DOI: 10.1021/acs.biochem.8b00010

Experimental method

NEUTRON DIFFRACTION (2.2 Å)
X-RAY DIFFRACTION (2 Å)