6BCM

Structure of a Self-inhibited N475A variant of the Venezuelan Equine Encephalitis Virus (VEEV) nsP2 cysteine protease

Summary for 6BCM

Entry DOI	10.2210/pdb6bcm/pdb
Descriptor	Protease nsP2, GLYCEROL, SODIUM ION, ... (4 entities in total)
Functional Keywords	alphavirus, nsp2, nonstructural protein, cysteine protease, self-inhibited, n475a, s-adenosyl-l-methionine methyltransferase, viral protein
Biological source	Venezuelan equine encephalitis virus
Total number of polymer chains	1
Total formula weight	38505.95
Authors	Compton, J.R.,Legler, P.M. (deposition date: 2017-10-20, release date: 2017-11-08, Last modification date: 2023-10-04)
Primary citation	Compton, J.R.,Mickey, M.J.,Hu, X.,Marugan, J.J.,Legler, P.M. Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. Biochemistry, 56:6221-6230, 2017 Cited by PubMed: 29064679 DOI: 10.1021/acs.biochem.7b00746 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation