6B8Y
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Summary for 6B8Y
Entry DOI | 10.2210/pdb6b8y/pdb |
Descriptor | TGF-beta receptor type-1, N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | alk5, kinase domain, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P36897 |
Total number of polymer chains | 1 |
Total formula weight | 35539.77 |
Authors | Sheriff, S. (deposition date: 2017-10-09, release date: 2018-02-07, Last modification date: 2023-10-04) |
Primary citation | Harikrishnan, L.S.,Warrier, J.,Tebben, A.J.,Tonukunuru, G.,Madduri, S.R.,Baligar, V.,Mannoori, R.,Seshadri, B.,Rahaman, H.,Arunachalam, P.N.,Dikundwar, A.G.,Fink, B.E.,Fargnoli, J.,Fereshteh, M.,Fan, Y.,Lippy, J.,Ho, C.P.,Wautlet, B.,Sheriff, S.,Ruzanov, M.,Borzilleri, R.M. Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF beta RI). Bioorg. Med. Chem., 26:1026-1034, 2018 Cited by PubMed: 29422332DOI: 10.1016/j.bmc.2018.01.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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