6B7H
Structure of mGluR3 with an agonist
Summary for 6B7H
Entry DOI | 10.2210/pdb6b7h/pdb |
Descriptor | Metabotropic glutamate receptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | mglur3 glutamate, membrane protein-agonist complex, membrane protein/agonist |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 60220.97 |
Authors | Monn, J.A.,Clawson, D.K. (deposition date: 2017-10-04, release date: 2018-04-25, Last modification date: 2020-07-29) |
Primary citation | Monn, J.A.,Henry, S.S.,Massey, S.M.,Clawson, D.K.,Chen, Q.,Diseroad, B.A.,Bhardwaj, R.M.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.S.,Carter, J.H.,Getman, B.G.,Adragni, K.,Broad, L.M.,Sanger, H.E.,Ursu, D.,Catlow, J.T.,Swanson, S.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.,Hao, J. Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist. J. Med. Chem., 61:2303-2328, 2018 Cited by PubMed: 29350927DOI: 10.1021/acs.jmedchem.7b01481 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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