6B3E
Crystal structure of human CDK12/CyclinK in complex with an inhibitor
Summary for 6B3E
Entry DOI | 10.2210/pdb6b3e/pdb |
Descriptor | Cyclin-dependent kinase 12, Cyclin-K, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: Q9NYV4 O75909 |
Total number of polymer chains | 4 |
Total formula weight | 138147.99 |
Authors | Ferguson, A.D. (deposition date: 2017-09-21, release date: 2017-12-27, Last modification date: 2023-10-04) |
Primary citation | Johannes, J.W.,Denz, C.R.,Su, N.,Wu, A.,Impastato, A.C.,Mlynarski, S.,Varnes, J.G.,Prince, D.B.,Cidado, J.,Gao, N.,Haddrick, M.,Jones, N.H.,Li, S.,Li, X.,Liu, Y.,Nguyen, T.B.,O'Connell, N.,Rivers, E.,Robbins, D.W.,Tomlinson, R.,Yao, T.,Zhu, X.,Ferguson, A.D.,Lamb, M.L.,Manchester, J.I.,Guichard, S. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem, 13:231-235, 2018 Cited by PubMed: 29266803DOI: 10.1002/cmdc.201700695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.06 Å) |
Structure validation
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