6B30
Structure of RORgt in complex with a novel inverse agonist 1
Summary for 6B30
Entry DOI | 10.2210/pdb6b30/pdb |
Descriptor | Nuclear receptor ROR-gamma, N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide (3 entities in total) |
Functional Keywords | complex, inverse agonist, nuclear hormone receptor, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 2 |
Total formula weight | 50908.96 |
Authors | Skene, R.J.,Hoffman, I. (deposition date: 2017-09-20, release date: 2018-01-03, Last modification date: 2024-03-13) |
Primary citation | Shirai, J.,Tomata, Y.,Kono, M.,Ochida, A.,Fukase, Y.,Sato, A.,Masada, S.,Kawamoto, T.,Yonemori, K.,Koyama, R.,Nakagawa, H.,Nakayama, M.,Uga, K.,Shibata, A.,Koga, K.,Okui, T.,Shirasaki, M.,Skene, R.,Sang, B.,Hoffman, I.,Lane, W.,Fujitani, Y.,Yamasaki, M.,Yamamoto, S. Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds. Bioorg. Med. Chem., 26:483-500, 2018 Cited by PubMed: 29262987DOI: 10.1016/j.bmc.2017.12.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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