6AYS

Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hexylthio-DADMe-Immucillin-A

Summary for 6AYS

Entry DOI	10.2210/pdb6ays/pdb
Descriptor	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 1,2-ETHANEDIOL, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol, ... (4 entities in total)
Functional Keywords	mtan enzyme, foodborne diseases, hydrolase, transferase
Biological source	Campylobacter jejuni
Total number of polymer chains	8
Total formula weight	213717.92
Authors	Harijan, R.K.,Ducati, R.G.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2017-09-08, release date: 2018-09-12, Last modification date: 2023-10-04)
Primary citation	Ducati, R.G.,Harijan, R.K.,Cameron, S.A.,Tyler, P.C.,Evans, G.B.,Schramm, V.L. Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. ACS Chem. Biol., 13:3173-3183, 2018 Cited by PubMed: 30339406 DOI: 10.1021/acschembio.8b00781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation