6AS7

CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP

Summary for 6AS7

• Entry DOI: 10.2210/pdb6as7/pdb
• Related: 4qcl
• Descriptor: DNA polymerase alpha catalytic subunit, DNA (5'-D(*GP*CP*CP*TP*GP*GP*AP*GP*CP*GP*C)-3'), DNA (5'-D(*AP*GP*GP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: b-family dna polymerase, dna replication, replication, replication-dna complex, replication/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 113570.22

Authors

Tahirov, T.H.,Baranovskiy, A.G.,Babayeva, N.D. (deposition date: 2017-08-23, release date: 2018-03-14, Last modification date: 2023-10-04)

• Primary citation: Baranovskiy, A.G.,Duong, V.N.,Babayeva, N.D.,Zhang, Y.,Pavlov, Y.I.,Anderson, K.S.,Tahirov, T.H.; Activity and fidelity of human DNA polymerase alpha depend on primer structure.; J. Biol. Chem., 293:6824-6843, 2018; PubMed: 29555682; DOI: 10.1074/jbc.RA117.001074

Experimental method

X-RAY DIFFRACTION (2.95 Å)