5ZMA

Structural basis for an allosteric Eya2 phosphatase inhibitor

Summary for 5ZMA

Entry DOI	10.2210/pdb5zma/pdb
Descriptor	Eyes absent homolog 2, 3-fluoro-N'-[(E)-{5-[(pyrimidin-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide (2 entities in total)
Functional Keywords	eya2, eyes absent protein, phosphatase, transcription coactivator, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	100106.09
Authors	Anantharajan, J.,Jansson, A.E.,Kang, C. (deposition date: 2018-04-02, release date: 2019-06-05, Last modification date: 2023-11-22)
Primary citation	Anantharajan, J.,Zhou, H.,Zhang, L.,Hotz, T.,Vincent, M.Y.,Blevins, M.A.,Jansson, A.E.,Kuan, J.W.L.,Ng, E.Y.,Yeo, Y.K.,Baburajendran, N.,Lin, G.,Hung, A.W.,Joy, J.,Patnaik, S.,Marugan, J.,Rudra, P.,Ghosh, D.,Hill, J.,Keller, T.H.,Zhao, R.,Ford, H.L.,Kang, C. Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells. Mol.Cancer Ther., 18:1484-1496, 2019 Cited by PubMed: 31285279 DOI: 10.1158/1535-7163.MCT-18-1239 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.175 Å)

Structure validation