5ZAM

Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate

Summary for 5ZAM

Entry DOI	10.2210/pdb5zam/pdb
EMDB information	6906
Descriptor	Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) (3 entities in total)
Functional Keywords	dicer, trbp, cryo-em, rna interference, protein binding, hydrolase-protein binding-rna complex, hydrolase/protein binding/rna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	281408.43
Authors	Liu, Z.,Wang, J.,Cheng, H.,Ke, X.,Sun, L.,Zhang, Q.C.,Wang, H.-W. (deposition date: 2018-02-07, release date: 2018-05-09, Last modification date: 2020-08-05)
Primary citation	Liu, Z.,Wang, J.,Cheng, H.,Ke, X.,Sun, L.,Zhang, Q.C.,Wang, H.W. Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173:1191-1203.e12, 2018 Cited by PubMed: 29706542 DOI: 10.1016/j.cell.2018.03.080 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.7 Å)

Structure validation