5Z5O

Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K

Summary for 5Z5O

• Entry DOI: 10.2210/pdb5z5o/pdb
• Related: 1BY8
• Descriptor: Cathepsin K, GLYCEROL, 1,2-ETHANEDIOL, ... (10 entities in total)
• Functional Keywords: cathepsin k, cysteine protease, lysosomal, bone disorder, pycnodysostosis, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 52305.05

Authors

Biswas, S.,Roy, S. (deposition date: 2018-01-19, release date: 2018-09-26, Last modification date: 2023-11-22)

• Primary citation: Roy, S.,Das Chakraborty, S.,Biswas, S.; Not all pycnodysostosis-related mutants of human cathepsin K are inactive - crystal structure and biochemical studies of an active mutant I249T.; FEBS J., 285:4265-4280, 2018; PubMed: 30199612; DOI: 10.1111/febs.14655

Experimental method

X-RAY DIFFRACTION (1.92 Å)