5Z1E

MAP2K7 C218S mutant-inhibitor

Summary for 5Z1E

Entry DOI	10.2210/pdb5z1e/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 7, N-[3-(6-methyl-1H-indazol-3-yl)phenyl]prop-2-enamide (3 entities in total)
Functional Keywords	protein kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37260.16
Authors	Kinoshita, T.,London, N. (deposition date: 2017-12-26, release date: 2019-01-02, Last modification date: 2023-11-22)
Primary citation	Shraga, A.,Olshvang, E.,Davidzohn, N.,Khoshkenar, P.,Germain, N.,Shurrush, K.,Carvalho, S.,Avram, L.,Albeck, S.,Unger, T.,Lefker, B.,Subramanyam, C.,Hudkins, R.L.,Mitchell, A.,Shulman, Z.,Kinoshita, T.,London, N. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chem Biol, 26:98-108.e5, 2019 Cited by PubMed: 30449673 DOI: 10.1016/j.chembiol.2018.10.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation