5Z15

Crystal structure of human TLR8 in complex with CU-CPT9c

Summary for 5Z15

• Entry DOI: 10.2210/pdb5z15/pdb
• Related: 5WYX 5WYZ
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 191280.84

Authors

Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2017-12-25, release date: 2018-07-04, Last modification date: 2020-07-29)

• Primary citation: Hu, Z.,Zhang, S.,Tanji, H.,Jiang, S.,Li, J.,Sakaniwa, K.,Jin, J.,Bian, Y.,Ohto, U.,Shimizu, T.,Yin, H.; Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.9 Å)