5YVC

Structure of CaMKK2 in complex with CKI-012

Summary for 5YVC

Entry DOI	10.2210/pdb5yvc/pdb
Descriptor	Calcium/calmodulin-dependent protein kinase kinase 2, 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, GLYCEROL, ... (6 entities in total)
Functional Keywords	calcium/calmodulin-dependent protein kinase kinase 2, camkk2, atp-binding, kinase, serine/threonine-protein kinase, transferase, protein-inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34483.89
Authors	Niwa, H.,Handa, N.,Yokoyama, S. (deposition date: 2017-11-24, release date: 2018-12-05, Last modification date: 2023-11-22)
Primary citation	Takaya, D.,Niwa, H.,Mikuni, J.,Nakamura, K.,Handa, N.,Tanaka, A.,Yokoyama, S.,Honma, T. Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method. J.Mol.Graph.Model., 99:107599-107599, 2020 Cited by PubMed: 32348940 DOI: 10.1016/j.jmgm.2020.107599 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation