5YHL
Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative
Summary for 5YHL
Entry DOI | 10.2210/pdb5yhl/pdb |
Related | 5WV2 5YFI |
Descriptor | Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ... (4 entities in total) |
Functional Keywords | g-protein coupled receptor, lipid mediator, functional antibody, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 91717.84 |
Authors | Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Iwata, S.,Kobayashi, T. (deposition date: 2017-09-28, release date: 2018-12-05, Last modification date: 2023-11-22) |
Primary citation | Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Yamashita, K.,Hirata, K.,Sekiguchi, Y.,Yasuda, S.,Shiroishi, M.,Shimizu, T.,Urushibata, Y.,Kajiwara, Y.,Inazumi, T.,Hotta, Y.,Asada, H.,Nakane, T.,Shiimura, Y.,Nakagita, T.,Tsuge, K.,Yoshida, S.,Kuribara, T.,Hosoya, T.,Sugimoto, Y.,Nomura, N.,Sato, M.,Hirokawa, T.,Kinoshita, M.,Murata, T.,Takayama, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T. Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15:18-26, 2019 Cited by PubMed: 30510193DOI: 10.1038/s41589-018-0131-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.2 Å) |
Structure validation
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