5YFY

Plasmodium vivax SHMT bound with PLP-glycine and GS625

Summary for 5YFY

• Entry DOI: 10.2210/pdb5yfy/pdb
• Descriptor: Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], 1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-fluoranyl-phenyl]piperidine-4-carboxylic acid, ... (5 entities in total)
• Functional Keywords: alpha and beta protein, transferase, methyltransferase activity, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Plasmodium vivax
• Total number of polymer chains: 3
• Total formula weight: 150055.46

Authors

Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (deposition date: 2017-09-22, release date: 2018-09-26, Last modification date: 2023-11-22)

• Primary citation: Chitnumsub, P.,Jaruwat, A.; to be published; to be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)