5Y6E

VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-hydroxyphenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 12)

Summary for 5Y6E

• Entry DOI: 10.2210/pdb5y6e/pdb
• Descriptor: Beta-lactamase class B VIM-2, ZINC ION, (2R)-2-(4-hydroxyphenyl)-2-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]ethanoic acid, ... (5 entities in total)
• Functional Keywords: metallo-beta-lactamase vim-2, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 50474.07

Authors

Li, G.-B. (deposition date: 2017-08-11, release date: 2018-01-24, Last modification date: 2023-11-22)

• Primary citation: Liu, S.,Jing, L.,Yu, Z.-J.,Wu, C.,Zheng, Y.,Zhang, E.,Chen, Q.,Yu, Y.,Guo, L.,Wu, Y.,Li, G.-B.; ((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-beta-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.; Eur J Med Chem, 145:649-660, 2018; PubMed: 29353720; DOI: 10.1016/j.ejmech.2018.01.032

Experimental method

X-RAY DIFFRACTION (1.8 Å)