5Y2O

Structure of PPARgamma ligand binding domain-pioglitazone complex

Summary for 5Y2O

• Entry DOI: 10.2210/pdb5y2o/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, (5S)-5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione (3 entities in total)
• Functional Keywords: ppargamma, nuclear receptor, pioglitazone, thiazolidinedione, ligand binding domain, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 67109.69

Authors

Im, Y.J.,Lee, M. (deposition date: 2017-07-26, release date: 2017-12-20, Last modification date: 2023-11-22)

• Primary citation: Lee, M.A.,Tan, L.,Yang, H.,Im, Y.G.,Im, Y.J.; Structures of PPAR gamma complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs; Sci Rep, 7:16837-16837, 2017; PubMed: 29203903; DOI: 10.1038/s41598-017-17082-x

Experimental method

X-RAY DIFFRACTION (1.801 Å)