5Y0Z

Human SIRT2 in complex with a specific inhibitor, NPD11033

Summary for 5Y0Z

Entry DOI	10.2210/pdb5y0z/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-2, ZINC ION, (1~{R},9~{S})-11-[(2~{R})-3-[2,4-bis(2-methylbutan-2-yl)phenoxy]-2-oxidanyl-propyl]-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, ... (4 entities in total)
Functional Keywords	sirtuin, sirt, nad-dependent deacetylase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	67494.63
Authors	Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2017-07-19, release date: 2018-07-25, Last modification date: 2023-11-22)
Primary citation	Kudo, N.,Ito, A.,Arata, M.,Nakata, A.,Yoshida, M. Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373:-, 2018 Cited by PubMed: 29685974 DOI: 10.1098/rstb.2017.0070 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation