5XXK

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

Summary for 5XXK

Entry DOI	10.2210/pdb5xxk/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, Hydrocarbon stapled peptide THC-SER-PHE-0EH-GLU-TYR-6CW-ALA-LEU-LEU-MK8-NH2 (3 entities in total)
Functional Keywords	e3 ubiqutin ligase, oncoprotein, oncoprotein-inhibitor complex, oncoprotein/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	4
Total formula weight	30379.55
Authors	Brown, C.J. (deposition date: 2017-07-04, release date: 2017-12-27, Last modification date: 2023-11-22)
Primary citation	Chee, S.M.Q.,Wongsantichon, J.,Siau, J.,Thean, D.,Ferrer, F.,Robinson, R.C.,Lane, D.P.,Brown, C.J.,Ghadessy, F.J. Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids. PLoS ONE, 12:e0189379-e0189379, 2017 Cited by PubMed: 29228061 DOI: 10.1371/journal.pone.0189379 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation