5XV7
SRPK1 in complex with Alectinib
Summary for 5XV7
Entry DOI | 10.2210/pdb5xv7/pdb |
Descriptor | serine-arginine (SR) protein kinase 1, 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, ... (4 entities in total) |
Functional Keywords | srpk1, alectinib, srpkin-1, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 43157.73 |
Authors | Zeng, C.,Ngo, J.C.K. (deposition date: 2017-06-26, release date: 2018-03-14, Last modification date: 2023-11-22) |
Primary citation | Hatcher, J.M.,Wu, G.,Zeng, C.,Zhu, J.,Meng, F.,Patel, S.,Wang, W.,Ficarro, S.B.,Leggett, A.L.,Powell, C.E.,Marto, J.A.,Zhang, K.,Ki Ngo, J.C.,Fu, X.D.,Zhang, T.,Gray, N.S. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform Cell Chem Biol, 25:460-470.e6, 2018 Cited by PubMed: 29478907DOI: 10.1016/j.chembiol.2018.01.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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