5XP3

Crystal structure of apo T2R-TTL

Summary for 5XP3

• Entry DOI: 10.2210/pdb5xp3/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: colchicine binding domain, tubulin inhibitor, tublin, structural protein
• Biological source: Sus scrofa (Pig); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 F2Z5B2; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264613.98

Authors

Wang, Y.,Yang, J.,Wang, T.,Chen, L. (deposition date: 2017-05-31, release date: 2017-10-25, Last modification date: 2024-03-27)

• Primary citation: Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C.; The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.; J. Biol. Chem., 2018; PubMed: 29691282; DOI: 10.1074/jbc.RA117.001658

Experimental method

X-RAY DIFFRACTION (2.3 Å)