5XIW

Crystal structure of T2R-TTL-Colchicine complex

Summary for 5XIW

• Entry DOI: 10.2210/pdb5xiw/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, ... (12 entities in total)
• Functional Keywords: tubulin, colchicine, colchicine binding domain, tubulin inhibitor, cell cycle
• Biological source: Sus scrofa (Pig); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 A0A287AGU7; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264907.64

Authors

Wang, Y.,Yang, J.,Wang, T.,Chen, L. (deposition date: 2017-04-27, release date: 2018-04-18, Last modification date: 2024-03-27)

• Primary citation: Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C.; The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.; J. Biol. Chem., 2018; PubMed: 29691282; DOI: 10.1074/jbc.RA117.001658

Experimental method

X-RAY DIFFRACTION (2.9 Å)