5XF4
Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (S,S-configuration)
Summary for 5XF4
Entry DOI | 10.2210/pdb5xf4/pdb |
Related | 5XF3 5XF5 5XF6 |
Descriptor | Histone H3.1, SULFATE ION, Histone H4, ... (10 entities in total) |
Functional Keywords | nucleosome, histone adduct, ruthenium compound, binuclear metal-based agent, structural protein-dna complex, structural protein/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P68431 P62805 P04908 P06899 |
Total number of polymer chains | 10 |
Total formula weight | 200674.40 |
Authors | Ma, Z.,Adhireksan, Z.,Murray, B.S.,Dyson, P.J.,Davey, C.A. (deposition date: 2017-04-07, release date: 2017-10-11, Last modification date: 2023-11-22) |
Primary citation | Davey, G.E.,Adhireksan, Z.,Ma, Z.,Riedel, T.,Sharma, D.,Padavattan, S.,Rhodes, D.,Ludwig, A.,Sandin, S.,Murray, B.S.,Dyson, P.J.,Davey, C.A. Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Nat Commun, 8:1575-1575, 2017 Cited by PubMed: 29146919DOI: 10.1038/s41467-017-01680-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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