5X9D

Crystal structure of homoserine dehydrogenase in complex with L-cysteine and NAD

Summary for 5X9D

Entry DOI	10.2210/pdb5x9d/pdb
Related	4YDR 5AVO
Descriptor	Homoserine dehydrogenase, (2R)-3-[[(4S)-3-aminocarbonyl-1-[(2R,3R,4S,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4H-pyridin-4-yl]sulfanyl]-2-azanyl-propanoic acid, L(+)-TARTARIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, complex, inhibitor
Biological source	Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Total number of polymer chains	1
Total formula weight	34346.17
Authors	Goto, M.,Ogata, K.,Kaneko, R.,Yoshimune, K. (deposition date: 2017-03-06, release date: 2018-05-02, Last modification date: 2023-11-22)
Primary citation	Ogata, K.,Yajima, Y.,Nakamura, S.,Kaneko, R.,Goto, M.,Ohshima, T.,Yoshimune, K. Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex Sci Rep, 8:5749-5749, 2018 Cited by PubMed: 29636528 DOI: 10.1038/s41598-018-24063-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation