5X4X
Mutant human thymidylate synthase A191K crystallized in a sulfate-containing condition
Summary for 5X4X
Entry DOI | 10.2210/pdb5x4x/pdb |
Related | 5X4W 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 |
Descriptor | Thymidylate synthase, SULFATE ION (3 entities in total) |
Functional Keywords | methyltransferase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P04818 |
Total number of polymer chains | 1 |
Total formula weight | 36100.24 |
Authors | Chen, D.,Jansson, A.,Larsson, A.,Nordlund, P. (deposition date: 2017-02-14, release date: 2017-06-28, Last modification date: 2023-11-22) |
Primary citation | Chen, D.,Jansson, A.,Sim, D.,Larsson, A.,Nordlund, P. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292:13449-13458, 2017 Cited by PubMed: 28634233DOI: 10.1074/jbc.M117.787267 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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