5X2F
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)
Summary for 5X2F
Entry DOI | 10.2210/pdb5x2f/pdb |
Related | 5X26 5X27 5X28 5X2A 5X2C 5X2K |
Descriptor | Epidermal growth factor receptor, 9-cyclohexyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine (3 entities in total) |
Functional Keywords | egfr, t790m, v948r, sklb, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 4 |
Total formula weight | 152828.88 |
Authors | Yun, C.H. (deposition date: 2017-01-31, release date: 2018-02-07, Last modification date: 2024-03-27) |
Primary citation | Zhu, S.J.,Zhao, P.,Yang, J.,Ma, R.,Yan, X.E.,Yang, S.Y.,Yang, J.W.,Yun, C.H. Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9:13652-13665, 2018 Cited by PubMed: 29568384DOI: 10.18632/oncotarget.24113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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