5WQA
Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K
Summary for 5WQA
Entry DOI | 10.2210/pdb5wqa/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde, ZINC ION, ... (5 entities in total) |
Functional Keywords | natural pde4 inhibtor, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Apical cell membrane : Q08499 |
Total number of polymer chains | 2 |
Total formula weight | 78270.06 |
Authors | |
Primary citation | Huang, Y.,Liu, X.,Wu, D.,Tang, G.,Lai, Z.,Zheng, X.,Yin, S.,Luo, H.B. The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata Biochem. Pharmacol., 130:51-59, 2017 Cited by PubMed: 28159622DOI: 10.1016/j.bcp.2017.01.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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