5WIS
Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution
This is a non-PDB format compatible entry.
Summary for 5WIS
Entry DOI | 10.2210/pdb5wis/pdb |
Descriptor | 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | macrolide, antibiotic, inhibitor, inhibition of translation, peptidyl transferase center, ribosome |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4572626.23 |
Authors | Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S. (deposition date: 2017-07-20, release date: 2018-02-14, Last modification date: 2023-11-15) |
Primary citation | Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Res., 45:9573-9582, 2017 Cited by PubMed: 28934499DOI: 10.1093/nar/gkx673 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.703 Å) |
Structure validation
Download full validation report