5WI8

Crystal structure of murine 4-1BB from HEK293T cells in P21 space group

Summary for 5WI8

Entry DOI	10.2210/pdb5wi8/pdb
Descriptor	Tumor necrosis factor receptor superfamily member 9, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	tumor necrosis factor, apoptosis, immune system
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	67393.02
Authors	Zajonc, D.M.,Bitra, A. (deposition date: 2017-07-18, release date: 2017-12-20, Last modification date: 2020-07-29)
Primary citation	Bitra, A.,Doukov, T.,Wang, J.,Picarda, G.,Benedict, C.A.,Croft, M.,Zajonc, D.M. Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling. J. Biol. Chem., 293:1317-1329, 2018 Cited by PubMed: 29242193 DOI: 10.1074/jbc.M117.814905 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation