5WG3

Human GRK2 in complex with Gbetagamma subunits and CCG258748

Summary for 5WG3

Entry DOI	10.2210/pdb5wg3/pdb
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	125427.45
Authors	Bouley, R.,Tesmer, J.J.G. (deposition date: 2017-07-13, release date: 2017-12-27, Last modification date: 2023-10-04)
Primary citation	Bouley, R.,Waldschmidt, H.V.,Cato, M.C.,Cannavo, A.,Song, J.,Cheung, J.Y.,Yao, X.Q.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J.G. Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92:707-717, 2017 Cited by PubMed: 29070696 DOI: 10.1124/mol.117.110130 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.896 Å)

Structure validation